Panayiotopoulos C P, Obeid T, Waheed G
Division of Neurology, King Khalid University Hospital, Riyadh, Saudi Arabia.
Ann Neurol. 1989 Apr;25(4):391-7. doi: 10.1002/ana.410250411.
We report a prospective clinical and electroencephalographic study of 19 patients with juvenile myoclonic epilepsy and absence seizures. Absences began 1 to 9 (4.5 +/- 2.5) years before myoclonic jerks and generalized tonic-clonic seizures. Clinical manifestations during the absence ictus showed great variation, ranging from subtle or no overt features to severe impairment of consciousness, and severity was age related. Simple and complex absence seizures can occur in the same patient. The electroencephalographic features were distinct, with many interictal discharges, fragmentation of the paroxysms, and frequent polyspikes of varying numbers and amplitude for each spike-slow wave component. The combined clinical-electroencephalographic manifestations were characteristic and allow differentiation of absences in juvenile myoclonic epilepsy from typical absence seizures in other epileptic syndromes.
我们报告了一项针对19例青少年肌阵挛性癫痫和失神发作患者的前瞻性临床及脑电图研究。失神发作比肌阵挛抽搐和全身强直阵挛性发作早1至9（4.5±2.5）年出现。失神发作期的临床表现差异很大，从轻微或无明显特征到意识严重受损，且严重程度与年龄相关。简单失神发作和复杂失神发作可发生在同一患者身上。脑电图特征明显，有许多发作间期放电、发作波形破碎，且每个棘慢波成分的多棘波数量和幅度各不相同且频繁出现。临床与脑电图的综合表现具有特征性，有助于将青少年肌阵挛性癫痫的失神发作与其他癫痫综合征中的典型失神发作区分开来。
