El Amine El Hadj Olfa, Bouraoui Saadia, Ben Fadhel Carole Goutallier, Lahmar Ahlem, Mzabi-Regaya Sabeh
Laboratoire d'anatomie pathologique de l'Hôpital Mongi Slim La Marsa, Tunis, Tunisia.
Tunis Med. 2010 Dec;88(12):916-9.
Lipoleiomyoma of the uterus (LLU) is an extremely rare, benign, uterine tumour. This rare disease was unknown for a long time. Their histogenesis remains controversial.
To describe the clinical and pathological aspects of uterine lipoleiomyoma and to try to specify, by an immunohistochemical study, its degenerative or tumoral nature.
7 cases of LLU were identified represented by 2 pure Lipoma and 5 Lipoleiomyoma. We performed an immunohistochemical study including anti-vimentin, anti-smooth muscle actin, anti PS-100, anti-desmin, anti-factor VIII and anti-HMB- 45. The results were correlated with the pathogenesis of this lesion.
Immunohistochemical analysis showed an expression of PS 100 only in lipocytes whereas leiomyomatous cells express only smooth muscle actin.
Our study supports the benign tumoral nature of the fatty uterine lesions. Lipoleiomyomatous cells may originate from the transformation of a totipotent mesenchymal cell and not from a degenerative process.
子宫脂肪平滑肌瘤（LLU）是一种极其罕见的良性子宫肿瘤。这种罕见疾病长期以来不为人知。其组织发生仍存在争议。
描述子宫脂肪平滑肌瘤的临床和病理特征，并通过免疫组织化学研究试图明确其退行性或肿瘤性本质。
确定7例LLU病例，其中2例为纯脂肪瘤，5例为脂肪平滑肌瘤。我们进行了免疫组织化学研究，包括抗波形蛋白、抗平滑肌肌动蛋白、抗PS - 100、抗结蛋白、抗因子VIII和抗HMB - 45。结果与该病变的发病机制相关。
免疫组织化学分析显示PS 100仅在脂肪细胞中表达，而平滑肌瘤细胞仅表达平滑肌肌动蛋白。
我们的研究支持子宫脂肪性病变的良性肿瘤性质。脂肪平滑肌瘤细胞可能起源于全能间充质细胞的转化，而非退行性过程。
