Berland Y, Boistelle R, Olmer M
Service de Néphrologie, Hôpital Sainte Marguerite, Marseille, France.
Nephrol Dial Transplant. 1990;5(3):179-84. doi: 10.1093/ndt/5.3.179.
The urines of 23 stone-formers presenting repeated calcium oxalate lithiasis and 12 control subjects were collected at six different time periods daily. Supersaturations for calcium oxalate and brushite (DCPD) were calculated using ionic and solubility products. Urines of both groups were supersaturated for calcium oxalate but only urines of the stone-formers were supersaturated for brushite, the most simple calcium phosphate which nucleates very easily at the urinary pH. This fact suggests that the core of the calcium oxalate stone could be made of either a calcium oxalate crystallite or a brushite seed onto which hetergeneous nucleation of calcium oxalate can take place.
收集了23名反复出现草酸钙结石的结石形成者和12名对照受试者的尿液，每天在六个不同时间段进行收集。使用离子积和溶解度积计算草酸钙和磷酸氢钙（DCPD）的过饱和度。两组的尿液中草酸钙均过饱和，但只有结石形成者的尿液中磷酸氢钙过饱和，磷酸氢钙是最简单的磷酸钙，在尿液pH值下很容易成核。这一事实表明，草酸钙结石的核心可能由草酸钙微晶或磷酸氢钙晶种构成，草酸钙可在其上发生异质成核。
