心肌肌丝：从蛋白质组学到病理生理学。
Cardiac myofilaments: from proteome to pathophysiology.
机构信息
Departments of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Proteomics Clin Appl. 2008 Jun;2(6):800-10. doi: 10.1002/prca.200780075.
PMID:21136880
Abstract
This review addresses the functional consequences of altered post-translational modifications of cardiac myofilament proteins in cardiac diseases such as heart failure and ischemia. The modifications of thick and thin filament proteins as well as titin are addressed. Understanding the functional consequences of altered protein modifications is an essential step in the development of targeted therapies for common cardiac diseases.
摘要
这篇综述探讨了心脏疾病（如心力衰竭和缺血）中心肌球蛋白丝蛋白翻译后修饰改变的功能后果。文中还讨论了粗丝和细丝蛋白以及肌联蛋白的修饰。了解蛋白修饰改变的功能后果是开发常见心脏疾病靶向治疗的重要步骤。
Zotero 插件