van Dijk Sabine J, Hamdani Nazha, Stienen Ger J M, van der Velden Jolanda
Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.
J Muscle Res Cell Motil. 2008;29(6-8):159-62. doi: 10.1007/s10974-009-9169-x. Epub 2009 Feb 14.
Many changes in morphology, biochemical properties and myocyte function occur during development to heart failure. Most changes may be compensatory, yet unable to prevent cardiac dysfunction in the long run. This illustrates that it is important to carefully dissect the disease causing modifications from cardiac adaptation, in order to obtain a better understanding of the pathophysiological processes leading to heart failure.
在发展为心力衰竭的过程中，心肌形态、生化特性及心肌细胞功能会发生许多变化。多数变化可能具有代偿性，但从长远来看无法预防心脏功能障碍。这表明，仔细区分导致疾病的改变与心脏适应性改变非常重要，以便更好地理解导致心力衰竭的病理生理过程。
