Rodríguez-Noriega Eduardo, Seas Carlos
Hospital Civil de Guadalajara Fray Antonio Alcalde, Instituto de Patología Infecciosa y Experimental, Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México.
Rev Chilena Infectol. 2010 Aug;27 Suppl 2:S59-69.
MRSA clones belonging to the Brazilian, Pediatric, Cordobes/Chilean and New York/Japan clonal complexes are widely distributed across Latin America, although their individual distribution patterns and resistance to antimicrobial drugs are constantly changing. Furthermore, clones with increased virulence are beginning to appear more frequently both in hospital and community settings, and there is evidence that virulence factors can be transferred between hospital- and community-associated clones through recombination. These changing patterns have significant implications for clinical practice in the region. Most importantly, clinicians need to be aware of the changing antimicrobial resistance profile of circulating MRSA clones in their region in order to choose the most appropriate empiric antimicrobial therapy. Thus, regional molecular epidemiology programs are required across the region to provide accurate identification and characterization of circulating MRSA clones.
属于巴西、儿科、科尔多瓦/智利和纽约/日本克隆复合体的耐甲氧西林金黄色葡萄球菌（MRSA）克隆在拉丁美洲广泛分布，尽管它们各自的分布模式和对抗菌药物的耐药性不断变化。此外，毒力增强的克隆开始在医院和社区环境中更频繁地出现，并且有证据表明毒力因子可通过重组在医院相关克隆和社区相关克隆之间转移。这些不断变化的模式对该地区的临床实践具有重大影响。最重要的是，临床医生需要了解其所在地区流行的MRSA克隆不断变化的抗菌耐药性概况，以便选择最合适的经验性抗菌治疗。因此，该地区需要开展区域分子流行病学项目，以准确鉴定和表征流行的MRSA克隆。
