Fredriksson G, Buxton D, Uggla A, Kindahl H, Edqvist L E
Department of Obstetrics and Gynaecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Zentralbl Veterinarmed A. 1990 Mar;37(2):113-22. doi: 10.1111/j.1439-0442.1990.tb00882.x.
In order to study the effect of Toxoplasma infection on hormonal levels in pregnant ewes, twenty-eight Scottish Blackface ewes were dosed orally with Toxoplasma gondii oocytes at 91 +/- 1 days of gestation. Fifteen of these ewes were vaccinated with an experimental Toxoplasma iscom vaccine prior to inoculation. Further three ewes were used as non-infected controls. All challenged ewes became infected. Plasma was analysed for the content of 15-ketodihydro-PGF2 alpha, progesterone and oestrone sulphate. The endocrinological changes appeared to reflect the pathological changes in the uterus. Infected animals tended to show an increase in the levels of the prostaglandin metabolite between two and eleven days after challenge, followed by a decrease in progesterone and later also of oestrone sulphate levels. Following the initial phase, the pattern was more variable but related to the outcome of gestation. There was a marked tendency towards more normal endocrinological patterns in the vaccinated animals in comparison to unvaccinated challenged ones.
为研究弓形虫感染对妊娠母羊激素水平的影响，在妊娠91±1天时，给28只苏格兰黑脸母羊口服弓形虫卵囊。其中15只母羊在接种前用实验性弓形虫免疫刺激复合物疫苗进行了免疫。另外3只母羊用作未感染对照。所有受攻击的母羊均被感染。分析血浆中15-酮二氢-PGF2α、孕酮和硫酸雌酮的含量。内分泌变化似乎反映了子宫的病理变化。受感染动物在攻击后2至11天内前列腺素代谢物水平趋于升高，随后孕酮水平下降，硫酸雌酮水平随后也下降。在初始阶段之后，模式变化更大，但与妊娠结局相关。与未接种疫苗而受攻击的动物相比，接种疫苗的动物内分泌模式明显更趋于正常。
