Carlsson U, Fredriksson G, Kindahl H, Alenius S
Department of Cattle and Sheep Diseases, Swedish University of Agricultural Sciences, Uppsala.
Am J Reprod Immunol Microbiol. 1987 Jul;14(3):91-8. doi: 10.1111/j.1600-0897.1987.tb00126.x.
Fourteen unvaccinated and seronegative ewes were experimentally infected with bovine virus diarrhoea virus around day 60 of pregnancy. Two other groups of pregnant ewes served as control animals. The animals were followed with ultrasound scanning to study the status of the fetus and with frequent blood sampling for analysis of progesterone and 15-keto-13,14-dihydro-PGF2 alpha, two hormones that could reflect the propagation of the infection. The unvaccinated ewes responded to the infection with abortion, resorption of the fetus, mummification or no changes at all. The endocrinological changes reflected in a most adequate way the pathological changes in the uterus. Detailed endocrinological studies can contribute to the understanding of the pathogenesis of some infectious diseases that affect reproduction.
14只未接种疫苗且血清学阴性的母羊在妊娠约60天时被实验性感染牛病毒性腹泻病毒。另外两组怀孕母羊作为对照动物。通过超声扫描跟踪动物以研究胎儿状况，并频繁采集血液样本分析孕酮和15-酮-13,14-二氢-PGF2α，这两种激素可反映感染的传播情况。未接种疫苗的母羊对感染的反应为流产、胎儿吸收、木乃伊化或无任何变化。内分泌变化以最充分的方式反映了子宫的病理变化。详细的内分泌学研究有助于理解一些影响繁殖的传染病的发病机制。
