Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, P.O. Box 14155-6153, Tehran, Iran.
Z Naturforsch C J Biosci. 2010 Sep-Oct;65(9-10):567-70. doi: 10.1515/znc-2010-9-1006.
Vaccinium arctostaphylos is a traditional medicinal plant in Iran used for the treatment of diabetes mellitus. In our search for antidiabetic compounds from natural sources, we found that the extract obtained from V. arctostaphylos berries showed an inhibitory effect on pancreatic alpha-amylase in vitro [IC50 = 1.91 (1.89-1.94) mg/mL]. The activity-guided purification of the extract led to the isolation of malvidin-3-O-beta-glucoside as an a-amylase inhibitor. The compound demonstrated a dose-dependent enzyme inihibitory activity [IC50 = 0.329 (0.316-0.342) mM].
笃斯越桔是伊朗的一种传统药用植物，用于治疗糖尿病。在我们从天然来源寻找抗糖尿病化合物的过程中，我们发现从笃斯越桔浆果中获得的提取物在体外显示出对胰腺α-淀粉酶的抑制作用[IC50 = 1.91（1.89-1.94）mg/mL]。活性导向的提取物纯化导致分离出矢车菊素-3-O-β-葡萄糖苷作为α-淀粉酶抑制剂。该化合物表现出剂量依赖性的酶抑制活性[IC50 = 0.329（0.316-0.342）mM]。
