Inagaki M, Ohno K, Ohta S, Sakuraba H, Takeshita K
Division of Child Neurology, Tottori University School of Medicine, Yonago, Japan.
Pediatr Neurol. 1990 May-Jun;6(3):211-3. doi: 10.1016/0887-8994(90)90067-b.
Neurotropin, an extract from the inflamed skin of vaccinia virus-inoculated rabbits, was effective in the relief of sharp or burning pain induced by pyrexia, hot weather, bathing, or exercise in 2 siblings with Fabry disease. Neither neurotropin nor carbamazepine mono-therapy relieved the episodic colicky pain in 1 patient; however, therapy with both drugs eliminated the pain completely. This result suggests that the mechanisms underlying the analgesic actions of both drugs may be complementary in ameliorating the pain of Fabry disease, even though the mechanism underlying the pain has not been clearly elucidated.
神经妥乐平是从接种牛痘病毒的兔子发炎皮肤中提取的一种物质，对2名法布里病患者的发热、炎热天气、洗澡或运动引起的锐痛或灼痛有效。神经妥乐平和卡马西平单药治疗均不能缓解1例患者的发作性绞痛；然而，两种药物联合治疗可完全消除疼痛。这一结果表明，尽管疼痛的潜在机制尚未明确阐明，但两种药物镇痛作用的潜在机制在改善法布里病疼痛方面可能具有互补性。
