Boujrad N, Denis I, Papadopoulos V, Pisselet C, Bouchard P, Drosdowsky M A, Hochereau de Reviers M T, Carreau S
I.N.R.A., Nouzilly.
C R Acad Sci III. 1990;310(9):417-21.
In mature rat Leydig cells, the testosterone output (24 ng/10(6) Leydig cells/4hrs.) is increased 10 fold by LH; the addition of serum from either control or castrated or hypophysectomized rams inhibits (60%) the LH-stimulated testosterone production. Similarly, the incubation of immature rat Leydig cells with sera from hypophysectomized patients leads to a diminution (70 and 30% respectively) of both basal (0.98 ng) and LH stimulated (3.44 ng) testosterone biosynthesis. These data suggest the existence of an LH inhibitor (or inhibitors) in blood from ram and human; in addition, this substance is not only of testicular origin and is not an LH-related molecule.
在成熟大鼠的睾丸间质细胞中，促黄体生成素（LH）可使睾酮分泌量（24纳克/10⁶个睾丸间质细胞/4小时）增加10倍；添加来自对照、去势或垂体切除公羊的血清会抑制（60%）LH刺激的睾酮生成。同样，将未成熟大鼠的睾丸间质细胞与垂体切除患者的血清一起孵育，会导致基础（0.98纳克）和LH刺激（3.44纳克）的睾酮生物合成均减少（分别减少70%和30%）。这些数据表明，公羊和人类血液中存在LH抑制剂；此外，这种物质不仅不是睾丸来源的，也不是与LH相关的分子。
