Dunlap Neal E, Woodford Randell L, Shoushtari Asal N, Reibel James F, Douvas Michael G, Cousar John B, Read Paul W
University of Virginia, Department of Radiation Oncology;
Rare Tumors. 2010 Mar 31;2(1):e9. doi: 10.4081/rt.2010.e9.
We report the case of a primary nasopharyngeal interdigitating dendritic cell tumor (IDDCT). A 25-year old male presented with bilateral decreased hearing, double vision, and ataxia. Flexible nasopharyngoscopy reviewed a large mass obstructing and filling the entire nasopharynx. MRI and PET-CT confirmed the presence of the primary tumor and demonstrated bilateral cervical lymphadenopathy. Biopsy of the nasopharynx revealed a hematolymphoid neoplasm with dendritic cell differentiation, most consistent with an IDDCT. The lesion was unresectable. The patient was treated with definitive radiotherapy to 66 Gy to the primary tumor and 50 Gy to the bilateral cervical lymphatics using an IMRT technique. A complete response was achieved and the patient remains disease free at the primary site 23 months after completion of radiotherapy.
我们报告一例原发性鼻咽部指突状树突细胞肿瘤（IDDCT）。一名25岁男性出现双侧听力下降、复视和共济失调。纤维鼻咽镜检查发现一个巨大肿块阻塞并充满整个鼻咽部。MRI和PET-CT证实了原发性肿瘤的存在，并显示双侧颈部淋巴结病。鼻咽部活检显示一种具有树突细胞分化的血液淋巴肿瘤，最符合IDDCT。该病变无法切除。患者采用调强放疗技术，对原发性肿瘤给予66 Gy的根治性放疗，对双侧颈部淋巴管给予50 Gy的放疗。获得了完全缓解，放疗结束23个月后，患者原发部位仍无疾病。
