Clinica Mediterranea, Laboratory of Interventional Cardiology, Naples, Italy.
Arch Toxicol. 2011 Mar;85(3):165-73. doi: 10.1007/s00204-010-0626-5. Epub 2010 Dec 8.
Contrast-induced acute kidney injury (CI-AKI) accounts for approximately 10% of all causes of hospital-acquired renal failure, causes a prolonged in-hospital stay, and represents a powerful predictor of poor early and late outcome. N-acetylcysteine (NAC) is a thiol compound classically known as a mucolytic agent, which is a potent antioxidant that scavenges a wide variety of oxygen-derived-free-radicals and may be capable of preventing acute kidney injury. In the present study, we will review (1) the pathophysiology of the CI-AKI and (2) the experimental and clinical data on the effects of NAC in preventing CI-AKI.
对比剂诱导的急性肾损伤（CI-AKI）约占所有医院获得性肾衰竭病因的 10%，导致住院时间延长，并成为不良近期和远期预后的有力预测因素。N-乙酰半胱氨酸（NAC）是一种经典的巯基化合物，作为黏液溶解剂，具有很强的抗氧化作用，可以清除多种氧自由基，可能具有预防急性肾损伤的作用。在本研究中，我们将综述（1）CI-AKI 的病理生理学和（2）NAC 预防 CI-AKI 的实验和临床数据。
