Zarubaev V V, Krivitskaia V Z, Nebol'sin V E, Kiselev O I
Antibiot Khimioter. 2010;55(7-8):13-6.
The Ingavirin antiviral properties with respect to the parainfluenza virus, as an actual human respiratory tract pathogen, were investigated by two methods, i.e. immunoenzymatic analysis and microtetrazolium test. The results showed that along with the immediate antiviral activity Ingavirin had nonspecific cytoprotective properties. While affecting the virus proteins synthesis, Ingavirin lowered the virus cytopathogenic action. The drug significantly decreased the portion of the bronchial epithelium cells killed at the stage of acute infection.
针对作为实际人类呼吸道病原体的副流感病毒，通过免疫酶分析和微量四氮唑试验这两种方法研究了英加韦林的抗病毒特性。结果表明，除了具有直接抗病毒活性外，英加韦林还具有非特异性细胞保护特性。在影响病毒蛋白质合成的同时，英加韦林降低了病毒的细胞致病作用。该药物显著降低了急性感染阶段死亡的支气管上皮细胞比例。
