Forghani Mohammad Naser, Memar Bahram, Jangjoo Ali, Zakavi Rasoul, Mehrabibahar Mostafa, Kakhki Vahid Reza Dabbagh, Kashani Ida, Hashemian Farnaz, Sadeghi Ramin
General Surgery Department, Mashhad University of Medical Sciences, Iran.
Am Surg. 2010 Nov;76(11):1232-5.
Despite the successful application of sentinel node mapping in breast cancer patients, its use in patients with a history of previous excisional biopsy of the breast tumors is a matter of controversy. In the present study we evaluated the accuracy of sentinel node biopsy in this group of patients and compared the results with those in whom the diagnosis of breast cancer was established by core needle biopsy. Eighty patients with early stage breast carcinoma were included into our study. Forty patients had a history of previous excisional biopsy and the remainder 40 had undergone core needle biopsy. Intradermal injections of 99mTc-antimony sulfide colloid as well as patent blue were both used for sentinel node mapping. Sentinel nodes were harvested during surgery with the aid of surgical gamma probe. All patients underwent standard axillary lymph node dissection subsequently. Detection rate was 97.5 per cent for both groups of the study. Number of detected sentinel node during surgery was not significantly different between groups. False negative rate was 0 per cent for both groups of the study. In conclusion sentinel node biopsy is reliable in patients with previous history of excisional biopsy of the breast tumors and has a low false negative rate.
尽管前哨淋巴结定位在乳腺癌患者中已成功应用，但其在有乳腺肿瘤既往切除活检史的患者中的应用仍存在争议。在本研究中，我们评估了该组患者前哨淋巴结活检的准确性，并将结果与通过粗针活检确诊乳腺癌的患者进行了比较。80例早期乳腺癌患者纳入我们的研究。40例患者有既往切除活检史，其余40例接受了粗针活检。皮内注射99mTc-硫化锑胶体以及专利蓝均用于前哨淋巴结定位。术中借助手术γ探测器获取前哨淋巴结。所有患者随后均接受了标准腋窝淋巴结清扫。研究的两组检测率均为97.5%。两组术中检测到的前哨淋巴结数量无显著差异。研究的两组假阴性率均为0%。总之，前哨淋巴结活检在有乳腺肿瘤既往切除活检史的患者中是可靠的，且假阴性率低。
