Esfehani Maryam H, Yazdankhah-Kenari Adel, Omranipour Ramesh, Mahmoudzadeh Habib Allah, Shahriaran Shahriar, Zafarghandi Mohammad Reza, Amoli Hadi Ahmadi
Department of Surgery, Iranian National Cancer Institute, Imam Khomeini Complex, Tehran University of Medical Sciences, Tehran, Iran.
Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Indian J Surg Oncol. 2015 Dec;6(4):370-3. doi: 10.1007/s13193-015-0446-4. Epub 2015 Jul 18.
Axillary staging is one of the primary steps in management of Breast cancer patients. Current standard methods including blue dye and radicolloid have limitations and disadvantages. In this study, the feasibility of visualization of lymph node pathways and localization of SLN with the help of CEUS was assessed. 50 patients with early breast cancer diagnosis underwent CEUS and wire localization, methylenblue dye, and isotope scan methods for SLN detection. The pathology findings of the wired SLN were compared with those obtained from, methylenblue dye, and isotope scan methods. Lymph node wiring was successfully performed in 48 patients.Radio-isotope technique detected SLN in all 50 patients while blue-dye succeeded in 48. Sensitivity of CEUS to detect SLN compared with radio-isotope and blue dye methods was 96 % and 100 %, respectively. Considering costs and facilities required to perform radio-isotope technique and complications of blue dye we may accept CEUS with the help of micro-bubble contrasts as a viable alternative. However, more studies with larger sample volumes, using various drugs, and including non-selective population are warranted to better clarify feasibility and accuracy of this technique in comparison with current methods.
腋窝分期是乳腺癌患者治疗的主要步骤之一。目前的标准方法包括蓝色染料法和放射性胶体法，都存在局限性和缺点。在本研究中，评估了在超声造影（CEUS）帮助下可视化淋巴结路径和定位前哨淋巴结（SLN）的可行性。50例早期乳腺癌诊断患者接受了CEUS、钢丝定位、亚甲蓝染料法和同位素扫描法以检测SLN。将钢丝定位的SLN病理结果与亚甲蓝染料法和同位素扫描法获得的结果进行比较。48例患者成功进行了淋巴结钢丝定位。放射性同位素技术在所有50例患者中均检测到SLN，而蓝色染料法在48例中成功检测到。与放射性同位素法和蓝色染料法相比，CEUS检测SLN的敏感性分别为96%和100%。考虑到进行放射性同位素技术所需的成本和设备以及蓝色染料的并发症，我们可以接受在微泡造影剂帮助下的CEUS作为一种可行的替代方法。然而，需要更多样本量更大、使用各种药物且包括非选择性人群的研究，以更好地阐明该技术与当前方法相比的可行性和准确性。
