[Study on the cytotoxicity induced by ceramic alloys].

AIM

To investigate the cytotoxicity of 3 kinds of dental ceramic alloys.

METHODS

Methods of 4-methyl-thiazolyl tetrazolium assay (MTT) and single cell gel electrophoresis (comet assay) were used to detect the influence on mouse fibroblast L929 relative growth rate (relative growth rate, RGR) and damage of DNA induced by three kinds of ceramic alloys.

RESULTS

RGR of the golden alloy group was 87.7 ± 11.3 which showed no significant difference when compared with the cobalt-chromium alloy group and the control group, while among other groups, there were statistically significant differences in RGR (P<0.05); the rank of DNA damage of nickel-chromium alloy was severe, while the ranks of cobalt-chromium alloy and golden alloy group were moderate and mild respectively.

CONCLUSION

The influence of golden alloy and cobalt-chromium alloy on RGR is significantly lower than nickel-chromium alloy, meanwhile the damage of DNA caused by golden alloy is lightest, so it is a kind of dental ceramic alloy with good biocompatibility.