Gorman J M, Goetz R R, Dillon D, Liebowitz M R, Fyer A J, Davies S, Klein D F
Biological Studies Unit, New York State Psychiatric Institute, NY.
Neuropsychopharmacology. 1990 Jun;3(3):181-9.
Nineteen patients with panic disorder received sodium D,L-lactate (racemic) and pure sodium D-lactate infusions in a pilot study. Sodium D-lactate, which is less metabolically active than L-lactate, produced panic attacks in half the patients. D-Lactate also produced hypocapnia and alkalosis, indicating hyperventilation. These findings suggest that metabolism of lactate is not necessary for the induction of panic in susceptible patients. D-Lactate appears similar to other agents that cause panic in its capacity to stimulate respiration in the preliminary study.
在一项初步研究中，19名惊恐障碍患者接受了D，L-乳酸钠（消旋体）和纯D-乳酸钠输注。D-乳酸钠的代谢活性低于L-乳酸，在一半的患者中引发了惊恐发作。D-乳酸还导致低碳酸血症和碱中毒，表明存在过度通气。这些发现表明，乳酸代谢对于易感患者惊恐发作的诱发并非必要。在这项初步研究中，D-乳酸在刺激呼吸的能力方面似乎与其他引发惊恐发作的药物相似。
