Xu Chuan-Xiang, Liu Hong-Tao, Wang Jing
Institute of Healthy and Environmental Medicine, Academy of Military Medical Sciences, TianJin 300050, China.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2008 May;24(2):225-8.
To investigate the changes of neurotransmitter concentration in spinal cord after exercise-induced central fatigue and study the mechanism of central fatigue at spinal level.
Establish exercise-induced central fatigue model according to Bedford incremental loading training. The rats were divided into three groups, control group (C), immediately after training group (IT), rest 3 hours after training group (RT). Then using high performance liquid chromatography (HPLC) to detect the concentration of neurotransmitter in spinal cord.
Amino acid neurotransmitters in spinal cord increased in IT group: Glu, GABA increased significantly (P < 0.05), Gly also increased but have no statistic difference; while in RT group, amino acid neurotransmitters got back to normal. However monoamine neurotransmitters NE, 5-HT tended to decrease in IT group. In RT group 5-HT decreased dramatically (P < 0.05).
Exercise-induced fatigue changed the concentration of neurotransmitter in spinal cord.The results suggested that neurotransmitter in spinal cord might have relationship with exercise-induced fatigue, especially 5-HT might have more important effect on recovery of fatigue.
探讨运动性中枢疲劳后脊髓神经递质浓度的变化，研究脊髓水平中枢疲劳的机制。
按照贝德福德递增负荷训练建立运动性中枢疲劳模型。将大鼠分为三组，对照组（C）、训练后即刻组（IT）、训练后休息3小时组（RT）。然后采用高效液相色谱法（HPLC）检测脊髓中神经递质的浓度。
IT组脊髓中氨基酸类神经递质增加：谷氨酸（Glu）、γ-氨基丁酸（GABA）显著增加（P<0.05），甘氨酸（Gly）也增加但无统计学差异；而RT组氨基酸类神经递质恢复正常。然而，IT组单胺类神经递质去甲肾上腺素（NE）、5-羟色胺（5-HT）呈下降趋势。RT组5-HT显著下降（P<0.05）。
运动性疲劳改变了脊髓中神经递质的浓度。结果提示脊髓中的神经递质可能与运动性疲劳有关，尤其是5-HT可能对疲劳恢复有更重要的作用。
