Dyck R F, Orchard R C, Senger D L
Department of Medicine, University Hospital, Saskatoon, Saskatchewan.
Clin Invest Med. 1990 Jun;13(3):107-10.
The purpose of this study was to investigate the plasma fibronectin response to complicated and uncomplicated acute myocardial infarction. All patients admitted to a Coronary Care Unit over a six-month period were prospectively assessed by measuring admission and daily plasma fibronectin levels using an electroimmunoassay. Of 166 patients admitted to the Unit, 66 were diagnosed as having an acute myocardial infarction. Plasma fibronectin levels were significantly lower 48 h after the onset of symptoms in 15 patients with a complicated acute myocardial infarction, compared to fibronectin levels in patients with an uncomplicated course; patients who had received intracoronary streptokinase had consistently higher plasma fibronectin levels than those seen in patients who did not receive this thrombolytic agent. This hepatocyte-derived plasma protein not only has diagnostic potential, but alterations in its levels may also provide insight into the systemic response to acute myocardial injury.
本研究的目的是调查血浆纤连蛋白对复杂型和非复杂型急性心肌梗死的反应。在六个月期间入住冠心病监护病房的所有患者，通过使用免疫电泳法测量入院时和每日血浆纤连蛋白水平进行前瞻性评估。在该病房收治的166例患者中，66例被诊断为急性心肌梗死。与病情不复杂的患者相比，15例复杂型急性心肌梗死患者在症状出现后48小时血浆纤连蛋白水平显著降低；接受冠状动脉内链激酶治疗的患者血浆纤连蛋白水平始终高于未接受这种溶栓剂治疗的患者。这种源自肝细胞的血浆蛋白不仅具有诊断潜力，其水平的变化还可能为了解对急性心肌损伤的全身反应提供线索。
