Department of Infectious Diseases and Clinical Microbiology, Erzurum Region Education and Research Hospital, Erzurum, Turkey.
Viral Immunol. 2010 Dec;23(6):633-8. doi: 10.1089/vim.2010.0080.
In chronic hepatitis B virus (HBV) infection, inflammation-associated cytokines including proinflammatory cytokines are involved in the development and progression of liver fibrosis. The liver is a source of many cytokines that may influence liver function. High-mobility group box 1 (HMGB1) was identified as an inflammatory cytokine. HMGB1 is present in nuclei of all mammalian cells and is released both through active secretion from various cells and by passive release from necrotic cells. Here we explore the relationship between HMGB1 plasma levels and liver fibrosis. HMGB1 serum levels, HBV-DNA, and ALT values were significantly higher in patients with chronic HBV than in controls. In addition, HMGB1 serum levels were significantly higher in patients with low fibrosis (fibrosis score 1-2) compared to those with high fibrosis (fibrosis score 3-4). In the present study, we have shown that HMGB1 is a noninvasive, repeatable, and convenient marker for distinguishing advanced fibrosis from low fibrosis in chronic HBV patients. We believe that the inhibition of HMGB1 may reduce inflammation, apoptosis, and fibrosis, and may stop the progression of chronic liver disease. Furthermore, we are of the opinion that fibrotic progression in chronic liver patients may be prevented by the inhibition of HMGB1, and that this substance can be a new means of following chronic HBV treatment.
在慢性乙型肝炎病毒（HBV）感染中，炎症相关细胞因子（包括促炎细胞因子）参与肝纤维化的发生和发展。肝脏是许多细胞因子的来源，这些细胞因子可能影响肝功能。高迁移率族蛋白 B1（HMGB1）被鉴定为一种炎症细胞因子。HMGB1 存在于所有哺乳动物细胞的核内，可通过各种细胞的主动分泌以及坏死细胞的被动释放而释放。在这里，我们探讨了 HMGB1 血浆水平与肝纤维化之间的关系。慢性 HBV 患者的 HMGB1 血清水平、HBV-DNA 和 ALT 值明显高于对照组。此外，低纤维化（纤维化评分 1-2）患者的 HMGB1 血清水平明显高于高纤维化（纤维化评分 3-4）患者。在本研究中，我们已经表明 HMGB1 是一种非侵入性、可重复和方便的标志物，可用于区分慢性 HBV 患者的晚期纤维化和低纤维化。我们认为抑制 HMGB1 可能减少炎症、细胞凋亡和纤维化，并可能阻止慢性肝病的进展。此外，我们认为抑制 HMGB1 可能预防慢性肝病患者的纤维化进展，并且该物质可以作为监测慢性 HBV 治疗的新方法。
