Kalantari Fariba, Bergeron John J M, Nilsson Tommy
The Research Institute of the McGill University Health Centre and the Department of Medicine, McGill University, Montreal, Quebec, Canada.
Mol Membr Biol. 2010 Nov;27(8):462-8. doi: 10.3109/09687688.2010.538936.
Lipid droplets are discrete organelles present in most cell types and organisms including bacteria, yeast, plants, insects and animals. Long considered as passive storage deposits, recent cell biology, proteomic and lipidomic analysis show that lipid droplets are dynamic organelles involved in multiple cellular functions. They have a central function in lipid distribution to different membrane-bound organelles and serve not only as main reservoirs of neutral lipids such as triglycerides and cholesterol but in addition, contain structural proteins, proteins involved in lipid synthesis and transmembrane proteins. A detailed model for how transmembrane proteins such as SNARE proteins can exist in lipid droplets is proposed.
脂滴是存在于大多数细胞类型和生物体（包括细菌、酵母、植物、昆虫和动物）中的离散细胞器。长期以来，脂滴一直被视为被动的储存沉积物，但最近的细胞生物学、蛋白质组学和脂质组学分析表明，脂滴是参与多种细胞功能的动态细胞器。它们在脂质向不同膜结合细胞器的分布中起着核心作用，不仅作为甘油三酯和胆固醇等中性脂质的主要储存库，此外，还含有结构蛋白、参与脂质合成的蛋白质和跨膜蛋白。本文提出了一个关于诸如SNARE蛋白等跨膜蛋白如何存在于脂滴中的详细模型。
