Department of Pharmaceutics, Bombay College of Pharmacy, Mumbai, India.
Nanomedicine (Lond). 2010 Dec;5(10):1595-616. doi: 10.2217/nnm.10.126.
There has been a resurgence of interest in nanoemulsions for various pharmaceutical applications since low-energy emulsification methods, such as spontaneous or self-nanoemulsification, have been described. Self-nanoemulsifying drug delivery systems (SNEDDS) are anhydrous homogenous liquid mixtures consisting of oil, surfactant, drug and coemulsifier or solubilizer, which spontaneously form oil-in-water nanoemulsion of approximately 200 nm or less in size upon dilution with water under gentle stirring. The physicochemical properties, drug solubilization capacity and physiological fate considerably govern the selection of the SNEDDS components. The composition of the SNEDDS can be optimized with the help of phase diagrams, whereas statistical experimental design can be used to further optimize SNEDDS. SNEDDS can improve oral bioavailability of hydrophobic drugs by several mechanisms. The conversion of liquid SNEDDS to solid oral dosage forms or solid SNEDDS has also been achieved by researchers. Solid SNEDDS can offer better patient compliance and minimize problems associated with capsules filled with liquid SNEDDS.
自从低能量乳化方法（如自发或自微乳化）被描述以来，人们对纳米乳液在各种药物应用中的兴趣再次兴起。自微乳药物传递系统 (SNEDDS) 是由油、表面活性剂、药物和助乳化剂或增溶剂组成的无水均相液体混合物，在与水混合并轻轻搅拌时，会自发形成约 200nm 或更小粒径的油包水纳米乳液。物理化学性质、药物溶解度和生理命运极大地影响了 SNEDDS 成分的选择。可以借助相图来优化 SNEDDS 的组成，而统计实验设计可用于进一步优化 SNEDDS。SNEDDS 可以通过多种机制提高疏水性药物的口服生物利用度。研究人员还实现了将液体 SNEDDS 转化为固体口服剂型或固体 SNEDDS。固体 SNEDDS 可以提供更好的患者依从性，并最大限度地减少与填充液体 SNEDDS 的胶囊相关的问题。
