Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, via Pansini, 5 (80131) Naples, Italy.
Curr Med Chem. 2011;18(4):482-96. doi: 10.2174/092986711794480203.
Aurora B is a serine-threonine kinase belonging to the highly conserved Aurora family of mitotic kinases. Aurora B is a chromosomal passenger protein involved in chromosome segregation, spindle-checkpoint, and cytokinesis. Alteration of each of these steps could induce aneuploidy, one of main features, and driving force of cancer progression. The overexpression of Aurora B has been observed in several tumor types, and has been linked with a poor prognosis of cancer patients. In this review we will focus on the role of Aurora B in cancer development, its role as a prognostic marker, and the clinical outcome of recently developed Aurora(s) inhibitors.
极光 B 是一种丝氨酸-苏氨酸激酶，属于高度保守的有丝分裂激酶极光家族。极光 B 是一种染色体乘客蛋白，参与染色体分离、纺锤体检验点和胞质分裂。这些步骤中的任何一个改变都可能导致非整倍体，这是非整倍体的主要特征之一，也是癌症进展的驱动力。在几种肿瘤类型中观察到极光 B 的过表达，并与癌症患者的预后不良相关。在这篇综述中，我们将重点介绍极光 B 在癌症发展中的作用、作为预后标志物的作用，以及最近开发的极光（s）抑制剂的临床结果。
