极光激酶在纺锤体组装和染色体分离中的作用
Aurora kinases in spindle assembly and chromosome segregation.
作者信息
Ducat Daniel, Zheng Yixian
机构信息
Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, Baltimore, MD 21210, USA.
出版信息
Exp Cell Res. 2004 Nov 15;301(1):60-7. doi: 10.1016/j.yexcr.2004.08.016.
The Aurora kinase family consists of three members, Aurora A, B, and C. The Aurora A and B kinases have emerged as essential regulators of cell division. While Aurora A kinase is implicated in regulating mitotic entry, centrosome maturation, and spindle assembly, Aurora B is required for correct chromosome segregation and cytokinesis. In this review, we summarize the roles of Aurora A and B in spindle assembly and chromosome segregation.
极光激酶家族由三个成员组成，即极光激酶A、B和C。极光激酶A和B已成为细胞分裂的重要调节因子。极光激酶A参与调节有丝分裂进入、中心体成熟和纺锤体组装，而正确的染色体分离和胞质分裂则需要极光激酶B。在这篇综述中，我们总结了极光激酶A和B在纺锤体组装和染色体分离中的作用。
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