Ducat Daniel, Zheng Yixian
Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, Baltimore, MD 21210, USA.
Exp Cell Res. 2004 Nov 15;301(1):60-7. doi: 10.1016/j.yexcr.2004.08.016.
The Aurora kinase family consists of three members, Aurora A, B, and C. The Aurora A and B kinases have emerged as essential regulators of cell division. While Aurora A kinase is implicated in regulating mitotic entry, centrosome maturation, and spindle assembly, Aurora B is required for correct chromosome segregation and cytokinesis. In this review, we summarize the roles of Aurora A and B in spindle assembly and chromosome segregation.
极光激酶家族由三个成员组成，即极光激酶A、B和C。极光激酶A和B已成为细胞分裂的重要调节因子。极光激酶A参与调节有丝分裂进入、中心体成熟和纺锤体组装，而正确的染色体分离和胞质分裂则需要极光激酶B。在这篇综述中，我们总结了极光激酶A和B在纺锤体组装和染色体分离中的作用。
