Inserm, U895, Equipe 1, Biologie et Pathologies des Mélanocytes: de la Pigmentation Cutanée au Mélanome, C3M, Nice, France.
Pigment Cell Melanoma Res. 2011 Apr;24(2):295-308. doi: 10.1111/j.1755-148X.2010.00820.x. Epub 2011 Jan 11.
Normal cells possess a limited proliferative life span, after which they enter a state of irreversible growth arrest, called replicative senescence, which acts as a potent barrier against transformation. Transformed cells have escaped the process of replicative senescence and theoretically can not re-enter senescence. However, recent observations showed that transformed cells, and particularly the melanoma cells, can still undergo oncogene or stress-induced senescence. This senescence state is accompanied by many of the markers associated with replicative senescence, such as flattened shape, increased acidic β-galactosidase activity, characteristic changes in gene expression and growth arrest. Interestingly, in some cancers, senescence induction following chemotherapy has been correlated with a favorable patient outcome. In this review, we gathered recent results describing senescence-like phenotype induction in melanoma cells and discuss why senescence may also be exploited as a therapeutic strategy in melanoma.
正常细胞具有有限的增殖寿命，之后它们进入一种不可逆的生长停滞状态，称为复制性衰老，这是一种阻止细胞癌变的有效屏障。转化细胞已经逃脱了复制性衰老的过程，理论上不能重新进入衰老。然而，最近的观察表明，转化细胞，特别是黑素瘤细胞，仍然可以经历癌基因或应激诱导的衰老。这种衰老状态伴随着许多与复制性衰老相关的标志物，如扁平形状、酸性β-半乳糖苷酶活性增加、基因表达和生长停滞的特征变化。有趣的是，在某些癌症中，化疗后诱导衰老与患者预后良好相关。在这篇综述中，我们收集了最近描述黑素瘤细胞中类似衰老表型诱导的结果，并讨论了为什么衰老也可以作为黑素瘤的一种治疗策略。
