Critical Care Medicine, Vancouver General Hospital, ICU, JPPN, 2nd Floor, Room 2438, 899 West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada.
Crit Care. 2010;14(6):243. doi: 10.1186/cc9247. Epub 2010 Dec 1.
Arthur Guyton's concepts of the determinative role of right heart filling in cardiac output continue to be controversial. This paper reviews his seminal experiments in detail and clarifies the often confusing concepts underpinning his model. One primary criticism of Guyton's model is that the parameters describing venous return had not been measured in a functioning cardiovascular system in humans. Thus, concerns have been expressed in regard to the ability of Guyton's simplistic model, with few parameters, to model the complex human circulation. Further concerns have been raised in regard to the artificial experimental preparations that Guyton used. Recently reported measurements in humans support Guyton's theoretical and animal work.
亚瑟·盖顿（Arthur Guyton）关于右心充盈在心输出量中起决定性作用的观点仍然存在争议。本文详细回顾了他的开创性实验，并澄清了其模型所依据的一些经常令人困惑的概念。对盖顿模型的主要批评之一是，描述静脉回流的参数尚未在人体功能心血管系统中进行测量。因此，人们对盖顿的简单模型（参数很少）能够对复杂的人体循环进行建模的能力表示担忧。人们还对盖顿使用的人工实验制剂提出了更多的担忧。最近在人类中报告的测量结果支持了盖顿的理论和动物工作。
