Hill J, Bird H A, Fenn G C, Lee C E, Woodward M, Wright V
Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate, U.K.
J Clin Pharm Ther. 1990 Jun;15(3):205-11. doi: 10.1111/j.1365-2710.1990.tb00376.x.
Lysine acetyl salicylate [1.8 g t.d.s. (Aspergesic 1,000 sachet)] has been compared to 400-mg ibuprofen tablets t.d.s. in a randomized double-blind trial in patients with rheumatoid arthritis using double-dummy technique. Both drugs proved effective in relieving symptoms. Three patients experienced drug-related side-effects with Aspergesic, and one patient with ibuprofen, that necessitated early discontinuation of treatment. Aspergesic was associated with a greater number of haemoglobin values falling below the normal range than ibuprofen. At the end of the study, eight out of 10 patients who expressed a preference selected Aspergesic for improving mobility whilst 15/24 selected Aspergesic for improving pain.
在一项针对类风湿性关节炎患者的随机双盲试验中，使用双模拟技术将赖氨酸乙酰水杨酸[1.8克，每日三次（阿斯匹林1000型药包）]与400毫克布洛芬片剂每日三次进行了比较。两种药物在缓解症状方面均被证明有效。三名患者使用阿斯匹林出现了与药物相关的副作用，一名使用布洛芬的患者出现了此类副作用，这使得治疗不得不提前终止。与布洛芬相比，阿斯匹林使更多血红蛋白值降至正常范围以下。在研究结束时，10名表示有偏好的患者中有8名选择阿斯匹林来改善活动能力，而24名患者中有15名选择阿斯匹林来缓解疼痛。
