类风湿关节炎中阿司匹林与布洛芬的相互作用。
The aspirin-ibuprofen interaction in rheumatoid arthritis.
作者信息
Grennan D M, Ferry D G, Ashworth M E, Kenny R E, Mackinnon M
出版信息
Br J Clin Pharmacol. 1979 Nov;8(5):497-503. doi: 10.1111/j.1365-2125.1979.tb01033.x.
1 This was a double-blind crossover trial of ibuprofen and soluble aspirin against each drug alone and against placebo in patients with rheumatoid arthritis. Two dosage regimes were tested. 2 A weak clinical additive effect was demonstrated between soluble aspirin and ibuprofen in patients with rheumatoid arthritis using moderate (1600 mg ibuprofen and 3.6 g aspirin daily) but not low (800 mg ibuprofen and 2.4 g aspirin daily) dosages of both drugs. 3 A significant correlation between clinical efficacy and serum ibuprofen but not salicylate level was found in the single drug periods of the trial. 4 No consistent effect of ibuprofen administration on serum salicylate levels was found. 5 Concurrent salicylate administration produced significant lowering of serum ibuprofen levels without affecting elimination half-lives of the drug.
这是一项针对类风湿性关节炎患者的双盲交叉试验，比较了布洛芬、可溶性阿司匹林分别单独使用以及与安慰剂对照的效果。试验测试了两种剂量方案。
在类风湿性关节炎患者中，使用中等剂量（布洛芬每日1600毫克、阿司匹林每日3.6克）而非低剂量（布洛芬每日800毫克、阿司匹林每日2.4克）时，可溶性阿司匹林与布洛芬之间显示出微弱的临床相加效应。
在试验的单药治疗阶段，发现临床疗效与血清布洛芬水平之间存在显著相关性，但与水杨酸盐水平无关。
未发现布洛芬给药对血清水杨酸盐水平有一致的影响。
同时给予水杨酸盐可显著降低血清布洛芬水平，但不影响该药物的消除半衰期。
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