In vitro fertilization surrogacy in rare coexisting Mayer-Rokitansky-Kuster-Hauser syndrome and triple X karyotype.

OBJECTIVE

To report the responses to IVF surrogacy attempts in a female with a heretofore never described combination of Mayer-Rokitansky-Kuster-Hauser (MRHK) syndrome and triple X karyotype.

DESIGN

Case report.

SETTING

Reproductive unit of a university-affiliated medical center.

PATIENT(S): A 29-year-old female diagnosed as having both MRHK syndrome and a triple X (47XXX) karyotype.

INTERVENTION(S): Five cycles of IVF surrogacy.

MAIN OUTCOME MEASURE(S): Recovery of oocytes after controlled ovarian stimulation.

RESULT(S): A maximum of five oocytes were retrieved by percutaneous abdominal aspiration of a single subcostal left ovary. After five unsuccessful IVF trials due to low ovarian response attributed to her coexisting MRHK syndrome and triple X karyotype, the patient's choice was oocyte donation.

CONCLUSION(S): An abnormal karyotype can coexist with MRKH syndrome, albeit very rarely, and probably accounts for a low ovarian response to attempts to achieve IVF surrogacy.