Nitzan D W, Livni N, Marmary Y, Ben-Baruch N, Sela J, Catane R
Department of Oral Maxillofacial Surgery, Hadassah-Hebrew University Faculty of Dental Medicine, Jerusalem, Israel.
Int J Oral Maxillofac Surg. 1990 Jun;19(3):162-4. doi: 10.1016/s0901-5027(05)80136-5.
A 75-year-old woman presented with a painless swelling in the right mandibular retromolar area and numbness of the left lower lip. Radiographic examination of the mandible demonstrated an osteolytic lesion of the ascending ramus. Biopsy revealed adenocarcinoma of obscure origin. Staining of the specimen with a monoclonal antibody specific to colon carcinoma revealed its origin. On subsequent examinations, a primary tumor in the rectosigmoid region with extensive lung, liver and skeletal metastases were diagnosed. This unusual case of colonorectal carcinoma, presenting as a metastatic lesion of the mandible, was readily diagnosed by a novel immunohistochemical technique that utilizes highly specific monoclonal antibodies.
一名75岁女性，表现为右下颌磨牙后区无痛性肿胀及左下唇麻木。下颌骨的影像学检查显示升支有溶骨性病变。活检显示为来源不明的腺癌。用结肠癌特异性单克隆抗体对标本进行染色揭示了其来源。后续检查诊断为直肠乙状结肠区域的原发性肿瘤并伴有广泛的肺、肝和骨骼转移。这例罕见的以下颌骨转移瘤形式出现的结直肠癌，通过一种利用高度特异性单克隆抗体的新型免疫组化技术得以轻松诊断。
