Shibutani Y, Inoue D, Yokota T, Okuda J, Mori T
Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital.
Nihon Naibunpi Gakkai Zasshi. 1992 Aug 20;68(8):765-72. doi: 10.1507/endocrine1927.68.8_765.
A case of metastatic thyroid cancer from sigmoid colon cancer is presented. A 52-year-old woman had a sigmoidectomy due to adenocarcinoma of the sigmoid colon in April 1988. Serum carcinoembryonic antigen (CEA) levels gradually rose from July 1990 along with multiple metastatic lesions which appeared in the lung. They were resected in January 1991. Two months later the subject noticed a painless and firm lump on the left anterior neck. She was found to have a solitary mass in the left thyroid lobe. Thyroid function remained within normal range. Cytological findings obtained by fine-needle aspiration biopsy showed tall columnar carcinoma cells with an acinar pattern. Subtotal thyroidectomy was performed, and histological examination revealed metastatic adenocarcinoma from colon cancer. Immunohistochemical staining by anti-CEA was positive but anti-thyroglobulin was negative.
本文报告一例乙状结肠癌转移至甲状腺的病例。一名52岁女性于1988年4月因乙状结肠腺癌接受了乙状结肠切除术。血清癌胚抗原（CEA）水平自1990年7月起逐渐升高，同时肺部出现多个转移病灶，并于1991年1月进行了切除。两个月后，患者发现左前颈部有一个无痛性硬块。检查发现左侧甲状腺叶有一个孤立性肿块。甲状腺功能仍在正常范围内。细针穿刺活检的细胞学检查显示为高柱状癌细胞，呈腺泡样结构。遂行甲状腺次全切除术，组织学检查显示为结肠癌转移性腺癌。抗CEA免疫组化染色呈阳性，但抗甲状腺球蛋白染色呈阴性。
