First Department of Propaedeutic Medicine, Athens University Medical School, Laiko General Hospital, Athens, Greece.
Diabetes Metab. 2011 Apr;37(2):144-51. doi: 10.1016/j.diabet.2010.09.006. Epub 2010 Dec 7.
The present study aimed to validate the Finnish Type 2 Diabetes Risk Score (FINDRISC) questionnaire for its ability to predict the presence of any glucose homoeostasis abnormalities and the metabolic syndrome (MetS) in the Greek population.
Validation was performed on a sample of individuals who had agreed to participate in a screening program for type 2 diabetes (T2D) prevention (the Greek part of the DE-PLAN study), using both FINDRISC and oral glucose tolerance tests (OGTT). Impaired fasting glucose (IFG) was defined as a fasting plasma glucose level of 6.1-6.9 mmol/L, and impaired glucose tolerance (IGT) as a 2-h plasma glucose of 7.8-11.0 mmol/L. The predictive value of the FINDRISC was cross-sectionally evaluated using the area under the receiver operating characteristic (AUROC) curve method.
A total of 869 individuals (379 men, aged 56.2 ± 10.8 years) were screened from the general population living in the city and suburbs of Athens. OGTT revealed the presence of unknown diabetes in 94 cases (10.8%), IFG in 85 (9.8%) and IGT in 109 (12.6%). The sensitivity of a FINDRISC score greater or equal to 15 (45% of the population) to predict unknown diabetes was 81.9% and its specificity was 59.7%. The AUROC curve for detecting unknown diabetes was 0.724 (95% CI: 0.677-0.770). For any dysglycaemia, the AUROC curve was 0.716 (0.680-0.752) while, for detection of the MetS, it was 0.733 (0.699-0.767).
The FINDRISC questionnaire performed well as a screening tool for the cross-sectional detection of unknown diabetes, IFG, IGT and the MetS in the Greek population.
本研究旨在验证芬兰 2 型糖尿病风险评分（FINDRISC）问卷预测希腊人群葡萄糖稳态异常和代谢综合征（MetS）的能力。
在同意参加 2 型糖尿病（T2D）预防筛查计划的个体样本（DE-PLAN 研究的希腊部分）中，使用 FINDRISC 和口服葡萄糖耐量试验（OGTT）进行验证。空腹血糖受损（IFG）定义为空腹血浆葡萄糖水平为 6.1-6.9mmol/L，葡萄糖耐量受损（IGT）定义为 2 小时血浆葡萄糖为 7.8-11.0mmol/L。使用受试者工作特征（ROC）曲线下面积（AUROC）曲线法，对 FINDRISC 的预测值进行了横断面评估。
从雅典市和郊区的一般人群中筛选出 869 名个体（379 名男性，年龄 56.2±10.8 岁）。OGTT 发现 94 例（10.8%）存在未知糖尿病，85 例（9.8%）存在 IFG，109 例（12.6%）存在 IGT。FINDRISC 评分大于或等于 15 分（占人群的 45%）预测未知糖尿病的敏感性为 81.9%，特异性为 59.7%。用于检测未知糖尿病的 AUROC 曲线为 0.724（95%CI：0.677-0.770）。对于任何糖代谢异常，AUROC 曲线为 0.716（0.680-0.752），而对于代谢综合征的检测，AUROC 曲线为 0.733（0.699-0.767）。
FINDRISC 问卷作为一种横断面检测希腊人群未知糖尿病、IFG、IGT 和代谢综合征的筛查工具，表现良好。
