Division of Chemical and Forensic Sciences, University of Bradford, Bradford, UK.
Spectrochim Acta A Mol Biomol Spectrosc. 2011 Oct;80(1):2-7. doi: 10.1016/j.saa.2010.11.001. Epub 2010 Nov 21.
Trace amounts of street samples of cocaine hydrochloride and N-methyl-3,4-methylenedioxy-amphetamine (MDMA) on natural and synthetic textiles were successfully detected in situ using confocal Raman microscopy. The presence of some excipient bands in the spectra of the drugs did not prevent the unambiguous identification of the drugs. Raman spectra of the drugs were readily obtained without significant interference from the fibre substrates. Interfering bands arising from the fibre natural or synthetic polymer structure and/or dye molecules did not overlap with the characteristic Raman bands of the drugs. If needed, interfering bands could be successfully removed by spectral subtraction. Also, Raman spectra could be acquired from drug particles trapped between the fibres of highly fluorescent textile specimens. The total acquisition time of the spectra of the drug particles was 90 s accomplished non-destructively and without detachment from their substrates. Sample preparation was not required and spectra of the drugs could be obtained non-invasively preserving the integrity of the evidential material for further analysis.
使用共焦拉曼显微镜成功地在天然和合成纺织品的街头可卡因盐酸盐和 N-甲基-3,4-亚甲二氧基苯丙胺（MDMA）的痕量样本中进行了现场检测。药物光谱中存在一些赋形剂带，但并未妨碍对药物的明确识别。很容易获得药物的拉曼光谱，而不会受到纤维基质的显著干扰。源自纤维天然或合成聚合物结构和/或染料分子的干扰带与药物的特征拉曼带没有重叠。如果需要，通过光谱减法可以成功去除干扰带。此外，可以从高度荧光纺织品样本的纤维之间捕获的药物颗粒中获取拉曼光谱。从药物颗粒的光谱中总共采集了 90 秒，而不会对其基质造成破坏，并且无需将其从其基质上卸下。不需要进行样品制备，并且可以非侵入性地获得药物的光谱，从而保留证据材料的完整性，以备进一步分析。
