Discipline of Chemistry, Faculty of Science and Technology, Queensland University of Technology, 2 George Street, Brisbane, Queensland 4001, Australia.
Forensic Sci Int. 2011 Oct 10;212(1-3):69-77. doi: 10.1016/j.forsciint.2011.05.016. Epub 2011 Jun 12.
Spatially offset Raman spectroscopy (SORS) is a powerful new technique for the non-invasive detection and identification of concealed substances and drugs. Here, we demonstrate the SORS technique in several scenarios that are relevant to customs screening, postal screening, drug detection and forensics applications. The examples include analysis of a multi-layered postal package to identify a concealed substance; identification of an antibiotic capsule inside its plastic blister pack; analysis of an envelope containing a powder; and identification of a drug dissolved in a clear solvent, contained in a non-transparent plastic bottle. As well as providing practical examples of SORS, the results highlight several considerations regarding the use of SORS in the field, including the advantages of different analysis geometries and the ability to tailor instrument parameters and optics to suit different types of packages and samples. We also discuss the features and benefits of SORS in relation to existing Raman techniques, including confocal microscopy, wide area illumination and the conventional backscattered Raman spectroscopy. The results will contribute to the recognition of SORS as a promising method for the rapid, chemically specific analysis and detection of drugs and pharmaceuticals.
空间位移拉曼光谱（SORS）是一种强大的新技术，可用于非侵入式检测和识别隐藏物质和毒品。在这里，我们展示了 SORS 技术在几个与海关检查、邮政检查、毒品检测和法医学应用相关的场景中的应用。这些例子包括分析多层邮政包裹以识别隐藏物质；识别塑料泡罩包装内的抗生素胶囊；分析含有粉末的信封；以及识别溶解在透明溶剂中的药物，该药物装在不透明的塑料瓶中。除了提供 SORS 的实际应用示例外，这些结果还强调了在现场使用 SORS 时需要考虑的几个因素，包括不同分析几何形状的优势以及根据不同类型的包裹和样品调整仪器参数和光学器件的能力。我们还讨论了 SORS 相对于现有拉曼技术（包括共聚焦显微镜、大面积照明和传统背散射拉曼光谱）的特点和优势。这些结果将有助于认识到 SORS 是一种有前途的方法，可用于快速、具有化学特异性的药物和药品分析和检测。
