Department of Radiation Oncology, Peking University First Hospital, Beijing, China.
Ultrasound Med Biol. 2011 Jan;37(1):69-77. doi: 10.1016/j.ultrasmedbio.2010.10.001.
This study aims to perform an in vivo investigation evaluating the injury to the pancreas and adjacent tissue of swine resulting with high-intensity focused ultrasound (HIFU) combined with radiotherapy (RT). The protocol was approved by the animal ethics committee at the Peking University First Hospital. A total of 12 domestic swine were divided into four groups: control, HIFU only, RT only and HIFU + RT. The injury to the pancreas, adjacent tissue and tissue within the acoustic path of the HIFU beam was assessed based on gross and histologic findings. For the targeted region of the pancreas, the score of the combined group was higher than that of the HIFU group and there was significant difference. For the acoustic path tissue, there was no significant difference except between the control group and the other groups. HIFU combined with RT increased the injury to the targeted pancreas, without increased injury to tissue outside of the targeted region.
本研究旨在进行一项体内研究，评估高强度聚焦超声（HIFU）联合放射治疗（RT）对猪胰腺和邻近组织的损伤。该方案已获得北京大学第一医院动物伦理委员会的批准。总共 12 头国产猪被分为四组：对照组、HIFU 组、RT 组和 HIFU + RT 组。根据大体和组织学发现评估胰腺、邻近组织和 HIFU 光束声路内的组织损伤。对于胰腺的靶向区域，联合组的评分高于 HIFU 组，差异有统计学意义。对于声路组织，除对照组与其他组之间外，差异均无统计学意义。HIFU 联合 RT 增加了靶胰腺的损伤，而对靶区以外的组织没有增加损伤。
