Department of Obstetrics and Gynecology, Women and Infants Hospital of Rhode Island and the Alpert Medical School of Brown University, Providence, RI, USA.
Am J Obstet Gynecol. 2011 Feb;204(2):128.e1-7. doi: 10.1016/j.ajog.2010.09.008. Epub 2010 Dec 8.
We sought to identify patient characteristics associated with cervical intraepithelial neoplasia (CIN) 3 in adolescents.
A cross-sectional cohort study was done using a colposcopic database. Data collected included demographic and clinical information as well as cytologic and histologic results. Variables associated with CIN 3 in the univariable analysis (P ≤ .10) were included in a multivariable logistic regression model.
Of 614 adolescents evaluated, 48 (8%; 95% confidence interval, 6-10%) had CIN 3. No cancers were detected. In the univariable analysis, parity, ≥ 4 lifetime male sexual partners, and a history of sexually transmitted infections were associated with an increased risk of CIN 3. In the final model, only ≥ 4 sexual partners (compared to <4; adjusted odds ratio, 3.66; 95% confidence interval, 1.26-10.61) was significantly associated with the finding of CIN 3.
CIN 3 was infrequently encountered in adolescents, and those with multiple sexual partners were at increased risk for CIN 3.
我们旨在确定与青少年宫颈上皮内瘤变（CIN）3 相关的患者特征。
使用阴道镜数据库进行了一项横断面队列研究。收集的数据包括人口统计学和临床信息以及细胞学和组织学结果。单变量分析中与 CIN 3 相关的变量（P ≤.10）被纳入多变量逻辑回归模型。
在评估的 614 名青少年中，有 48 名（8%；95%置信区间，6-10%）患有 CIN 3。未发现癌症。在单变量分析中，产次、≥4 个性伴侣和性传播感染史与 CIN 3 的风险增加相关。在最终模型中，只有≥4 个性伴侣（与<4 个相比；调整后的优势比，3.66；95%置信区间，1.26-10.61）与 CIN 3 的发现显著相关。
CIN 3 在青少年中很少见，性伴侣较多的青少年患 CIN 3 的风险增加。
