Department of Obstetrics and Gynecology, Federal University of Santa Catarina, Florianópolis-SC, Brazil.
J Low Genit Tract Dis. 2011 Jul;15(3):195-9. doi: 10.1097/LGT.0b013e31820918ea.
To test the association between high-grade cervical intraepithelial neoplasia (CIN), including CIN 2 and CIN 3, and the main risk factors established in the literature, such as age, early onset of sexual activity, use of hormonal contraception, smoking, sexually transmitted diseases, immunosuppression, the number of deliveries, and abortions.
A cross-sectional study using medical records of 531 women examined for a period of 2 years in a referral center in southern Brazil.
Multivariate logistic regression analysis confirmed the following risk factors for high-grade CIN: smoking (odds ratio [OR] = 1.92, with 95% confidence interval [CI] = 1.13-3.27), immunosuppression (OR = 3.45, 95% CI = 1.61-7.43), abortion (OR = 2.15, 95% CI = 1.07-4.35) and 2 or more abdominal deliveries (OR = 3.46, 95% CI = 1.90-6.27).
Cervical cancer screening should give special attention to the women with the above profile of risk factors by shortening the time interval between the screens.
检验高级别宫颈上皮内瘤变（CIN），包括 CIN2 和 CIN3，与文献中确立的主要危险因素之间的关联，如年龄、性活动起始早、使用激素避孕、吸烟、性传播疾病、免疫抑制、分娩次数和流产。
这是一项横断面研究，使用了巴西南部一家转诊中心的 531 名女性的医疗记录，这些女性在 2 年的时间内接受了检查。
多变量逻辑回归分析证实了高级别 CIN 的以下危险因素：吸烟（比值比 [OR] = 1.92，95%置信区间 [CI] = 1.13-3.27）、免疫抑制（OR = 3.45，95% CI = 1.61-7.43）、流产（OR = 2.15，95% CI = 1.07-4.35）和 2 次或更多次剖宫产（OR = 3.46，95% CI = 1.90-6.27）。
宫颈癌筛查应特别关注具有上述危险因素特征的女性，缩短筛查间隔时间。
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