Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada.
Biol Psychiatry. 2011 Feb 15;69(4):301-8. doi: 10.1016/j.biopsych.2010.09.034. Epub 2010 Dec 8.
The subcallosal cingulate gyrus (SCG), including Brodmann area 25 and parts of 24 and 32, is the portion of the cingulum that lies ventral to the corpus callosum. It constitutes an important node in a network that includes cortical structures, the limbic system, thalamus, hypothalamus, and brainstem nuclei. Imaging studies have shown abnormal SCG metabolic activity in patients with depression, a pattern that is reversed by various antidepressant therapies. The involvement of the SCG in mechanisms of depression and its emerging potential role as a surgical target for deep brain stimulation has focused recent interest in this area. We review anatomic and histologic attributes of the SCG and the morphologic and imaging changes observed in depression. Particular attention is given to the regional and downstream structures that could be influenced by the application of deep brain stimulation in this region.
扣带下回（SCG），包括布罗德曼区 25 区和 24 区、32 区的一部分，是位于胼胝体下方的扣带束的一部分。它构成了一个包括皮质结构、边缘系统、丘脑、下丘脑和脑干核团的网络的重要节点。影像学研究表明，抑郁症患者的 SCG 代谢活动异常，而各种抗抑郁治疗可逆转这种模式。SCG 参与抑郁症的发病机制及其作为深部脑刺激手术靶点的潜在作用，引起了人们对该领域的关注。我们回顾了 SCG 的解剖学和组织学特征，以及在抑郁症中观察到的形态和影像学变化。特别关注的是该区域深部脑刺激应用可能影响的区域和下游结构。
