Trapp Nicholas T, Liu Xianqing, Li Zhuoran, Bruss Joel, Keller Corey J, Boes Aaron D, Jiang Jing
University of Iowa Department of Psychiatry, Iowa City, IA, USA.
Iowa Neuroscience Institute, Iowa City, IA, USA.
bioRxiv. 2024 Dec 26:2024.12.20.629857. doi: 10.1101/2024.12.20.629857.
Transcranial magnetic stimulation combined with intracranial local field potential recordings in humans (TMS-iEEG) represents a new method for investigating electrophysiologic effects of TMS with spatiotemporal precision. We applied TMS-iEEG to the dorsolateral prefrontal cortex (dlPFC) in two subjects and demonstrate evoked activity in the subgenual anterior cingulate cortex (sgACC). This study provides direct electrophysiologic evidence that dlPFC TMS, as targeted for depression treatment, can modulate brain activity in the sgACC.
经颅磁刺激结合人类颅内局部场电位记录（TMS-iEEG）是一种以时空精度研究经颅磁刺激电生理效应的新方法。我们对两名受试者的背外侧前额叶皮层（dlPFC）进行了TMS-iEEG，并在膝下前扣带回皮层（sgACC）中证实了诱发活动。本研究提供了直接的电生理证据，表明作为抑郁症治疗靶点的dlPFC TMS可以调节sgACC中的大脑活动。
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