Shaw Kathryn A, Babu Kavita M, Hack Jason B
Department of Emergency Medicine, Brown University Alpert Medical School, Providence, Rhode Island, USA.
J Emerg Med. 2011 Dec;41(6):635-9. doi: 10.1016/j.jemermed.2010.11.014. Epub 2010 Dec 9.
Methadone has been used for many years in the clinical setting and has many well-described side effects. In recent years, the use of methadone and other opioids have been increasing throughout the United States (US), and presentations to US Emergency Departments (EDs) due to opioid use and abuse are increasing as well.
As methadone and opioid use increases, ED physicians should be aware of infrequently seen side effects and toxicities associated with the use of these drugs.
We report the case of a previously healthy 20-year-old man who presented with acute onset of bilateral hearing loss secondary to an unintentional methadone overdose. At follow-up, the patient's hearing had returned to normal, with the only intervention being abstinence from methadone.
Although bilateral hearing loss is a rare toxic finding of opioid ingestion, given the prevalence of opioid use, this etiology should be considered in any patient presenting with this chief complaint.
美沙酮已在临床环境中使用多年，有许多已充分描述的副作用。近年来，美沙酮和其他阿片类药物在美国的使用一直在增加，因阿片类药物使用和滥用而前往美国急诊科就诊的人数也在增加。
随着美沙酮和阿片类药物使用的增加，急诊科医生应了解与这些药物使用相关的罕见副作用和毒性。
我们报告了一例先前健康的20岁男性病例，该患者因意外过量服用美沙酮而出现急性双侧听力丧失。随访时，患者听力已恢复正常，唯一的干预措施是停用美沙酮。
尽管双侧听力丧失是阿片类药物摄入罕见的毒性表现，但鉴于阿片类药物的使用普遍，对于任何以该主诉就诊的患者都应考虑这一病因。
