Alvarez F A, Biquard C, Figini H A, Gutiérrez Márquez J M, Melcon M O, Monteverde D A, Somoza M J
Neurol Neurocir Psiquiatr. 1977;18(2-3 Suppl):357-73.
The Argentine hemorrhagic fever (AHF) is an infectious disease, endemo-epidemical, of viral etiology, produced by the Junin virus and limited to the Buenos Aires Province, South of Córdoba, East of La Pampa, and South of Santa Fe. It generally assails rural workers at harvest-time, especially during corn-harvest. The incubation period of the disease does not exceed 12 days. A feverish syndrome with asthenia, adynamia, myalgias, migraine, photophobia, epigastralgia etc., appear. The patient has a facial erythema, petechias on the skin, enantema on the palate, conjunctive micropolyadenopaty injection. The laboratory shows a low erytro, leukopenia with aneosinophilia, thrombopenia and a urine with albuminuria and virous cells. After the fourth day, hemorrhage and a neurological case appears. The laboratory tends to normalize and cast appears in the urine. The most striking neurological signs are the following: muscular hypotonia, proprioceptive hyporreflexia or arreflexia, marinesco reflex, shakings, difficulty to stand and walk, oscillations in consciousness level, and ocular disturbances. The cytochemical test of the C.L. Rachis in the usual ways of the AHF is within its normal characteristics; on the other hand there are modifications in the nervous cases: the total proteins are nearly always increased and the cells augmented with a great predominance of mononuclear cells. The electroencephalogrammes were always abnormal, varying from a brief disorganization up to a diffusive and permanent slowness. The half of which additionally presented paroxisms generalized by slow waves. The pathological anatomy over the central nervous system makes us think that the lesion would not primitively neuronal but that the action of the virus would be indirectly done through the capillar wall. This capillar lesion is produced by multiple focuses. The neuronal destruction with necrosis by microinfarcts is minimum. The symptoms and neurological signs are present in 10% of the clinical cases; the death-rate in the nervous clinical cases having reached 50% of them. The premature treatment allows the death-rate to diminish and the cases that survive have not many after effects.
阿根廷出血热（AHF）是一种由胡宁病毒引起的、具有地方流行性的病毒性传染病，局限于布宜诺斯艾利斯省、科尔多瓦省南部、拉潘帕省东部和圣菲省南部。该病通常在收获季节侵袭农村工人，尤其是在玉米收获期间。该病的潜伏期不超过12天。会出现伴有乏力、动力缺乏、肌痛、偏头痛、畏光、上腹部疼痛等症状的发热综合征。患者面部出现红斑，皮肤上有瘀点，腭部有黏膜疹，结膜微息肉样充血。实验室检查显示红细胞计数低、白细胞减少伴嗜酸性粒细胞减少、血小板减少，尿液中有蛋白尿和病毒细胞。第四天之后，会出现出血和神经症状。实验室检查结果趋于正常，尿液中出现管型。最显著的神经体征如下：肌张力减退、本体感觉减退或反射消失、马里内斯科反射、震颤、站立和行走困难、意识水平波动以及眼部障碍。以常规方法对AHF患者的脊髓进行细胞化学检测，其结果在正常范围内；另一方面，神经病例有一些变化：总蛋白几乎总是增加，细胞增多，且以单核细胞为主。脑电图总是异常的，从短暂的紊乱到弥漫性和持续性的缓慢变化不等。其中一半还伴有慢波全身性发作。中枢神经系统的病理解剖使我们认为，病变最初并非神经元性的，而是病毒的作用通过毛细血管壁间接产生的。这种毛细血管病变由多个病灶引起。微梗死导致的神经元坏死性破坏程度最小。神经症状和体征出现在10%的临床病例中；神经临床病例的死亡率达到了其中的50%。早期治疗可降低死亡率，存活的病例后遗症不多。
