Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.
Int J Biochem Cell Biol. 2011 Apr;43(4):465-9. doi: 10.1016/j.biocel.2010.12.004. Epub 2010 Dec 9.
The CK1 family of serine/threonine kinases regulates diverse cellular processes, through binding to and phosphorylation a myriad of protein substrates. CK1 prefers substrates primed by prior phosphorylation, and works closely with other kinases in the Wnt pathway. CK1 is itself regulated by posttranslational modification, including autophosphorylation. We provide a brief overview of the fundamentals of CK1 biology with an emphasis on scaffold binding and kinase regulation in Wnt signaling and circadian rhythms.
CK1 丝氨酸/苏氨酸激酶家族通过与众多蛋白质底物结合并磷酸化来调节各种细胞过程。CK1 优先选择先前磷酸化的底物，并与 Wnt 途径中的其他激酶密切合作。CK1 本身受到翻译后修饰的调节，包括自身磷酸化。我们简要概述了 CK1 生物学的基础知识，重点介绍了 Wnt 信号转导和生物钟节律中的支架结合和激酶调节。
