Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):754-8. doi: 10.1016/j.bjps.2010.10.018. Epub 2010 Dec 13.
It is well known that patients with cleft lip/palate or cleft palate can have associated anomalies. However, there is a relative paucity of information about the possible anomalies associated with an isolated cleft lip. A recent study (Vallino et al., 2008) showed that children with cleft lip and/or alveolus often develop cleft palate-related issues. This inspired us to investigate our population.
A questionnaire was sent to the parents of 214 children with cleft lip and/or alveolus; 161 questionnaires were returned (response rate (RR): 75%) and included in our study. The study consisted of 91 boys and 70 girls (0.3-13.1 years: mean 6.8 ± 3.5 years).
Speech and/or language problems were reported in 34% and ventilation tube insertion in 21% of children with ≥6 years' follow-up. Of the children in that group, 33% reported to have undergone an episode of acute otitis media and 11% reported five episodes or more. Additional congenital anomalies were found in 4% of children with a cleft lip and in 16% of children with a cleft lip/alveolus.
Our results demonstrate that an isolated cleft lip can often be described as an isolated anomaly, although children with cleft lip and/or alveolus develop cleft palate-related issues more often than anticipated. Therefore, we suggest an intensive monitoring and treatment of children with these types of clefts.
众所周知,唇裂/腭裂或腭裂患者可能存在相关畸形。然而,关于孤立性唇裂可能伴发的畸形,相关信息相对较少。最近的一项研究(Vallino 等人,2008 年)表明,唇裂和/或牙槽裂患儿常出现与腭裂相关的问题。这启发我们对本人群进行了研究。
我们向 214 例唇裂和/或牙槽裂患儿的家长发放了问卷,共回收 161 份(回复率(RR):75%),并将其纳入研究。该研究包括 91 名男孩和 70 名女孩(0.3-13.1 岁:平均 6.8±3.5 岁)。
随访时间≥6 年的患儿中,34%存在言语/语言问题,21%存在通气管置入。在该组患儿中,33%报告曾发生过急性中耳炎,11%报告发生过 5 次或以上。唇裂患儿中 4%存在其他先天性畸形,唇裂/牙槽裂患儿中 16%存在其他先天性畸形。
我们的结果表明,孤立性唇裂通常可被描述为孤立性畸形,但唇裂和/或牙槽裂患儿出现与腭裂相关问题的概率高于预期。因此,我们建议对这些类型的唇裂患儿进行密切监测和治疗。