Klabunde R E, Burke S E, Henkin J
Department of Pharmacology, Abbott Laboratories, Abbott Park, IL 60064.
Thromb Res. 1990 Jun 1;58(5):511-7. doi: 10.1016/0049-3848(91)90256-v.
The purpose of this study was to compare the lytic efficacy of tissue plasminogen activator (tPA) following different dosing regimens. Radiolabelled clots from dog whole blood were inserted into an extracorporeal jugular loop in anesthetized dogs. Clot size (counts/min) was continuously recorded. tPA was administered as a single 1 min bolus of 0.4 mg/kg, as four multiple bolus injections of 0.1 mg/kg each at 30 min intervals, or as an initial bolus (0.04 mg/kg) followed by a 30 min infusion of 0.36 mg/kg (10%/90%, bolus/infusion). Multiple injections of the same total dose of tPA resulted in 76% and 51% greater clot lysis than single bolus injection or bolus/infusion regimen, respectively, measured 120 min after initial dosing. There were no differences in fibrinogen, plasminogen or alpha-2-antiplasmin between the different treatment groups at 120 min.
本研究的目的是比较不同给药方案下组织型纤溶酶原激活剂（tPA）的溶栓效果。将来自犬全血的放射性标记凝块插入麻醉犬的体外颈静脉环中。连续记录凝块大小（计数/分钟）。tPA给药方式为：单次1分钟推注0.4mg/kg；每30分钟间隔进行4次每次0.1mg/kg的多次推注；或先进行一次推注（0.04mg/kg），随后30分钟输注0.36mg/kg（10%/90%，推注/输注）。在首次给药120分钟后测量，相同总剂量tPA的多次注射分别比单次推注或推注/输注方案导致的凝块溶解率高76%和51%。在120分钟时，不同治疗组之间的纤维蛋白原、纤溶酶原或α-2-抗纤溶酶没有差异。
