Department of Infectious Diseases, Molecular Virology, Im Neuenheimer Feld 345, Heidelberg University, D-69120 Heidelberg, Germany.
Trends Microbiol. 2011 Feb;19(2):95-103. doi: 10.1016/j.tim.2010.11.005. Epub 2010 Dec 14.
A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious HCV particles. Research in the past few years has shown that formation of HC-virions is closely connected to lipid droplets that could serve as an assembly platform. Moreover, HCV particle production appears to be strictly linked to very-low-density lipoproteins. In this review, we focus on new insights into the molecular aspects of the architecture and assembly of this unique type of virus particle.
丙型肝炎病毒 (HCV) 复制周期的一个特点是其与宿主细胞脂质合成的紧密联系。这一点在用于组装感染性 HCV 颗粒的特殊途径中得到了最好的说明。过去几年的研究表明，HCV 病毒粒子的形成与可能作为组装平台的脂滴密切相关。此外，HCV 颗粒的产生似乎与极低密度脂蛋白严格相关。在这篇综述中，我们重点介绍了对这种独特类型病毒颗粒的结构和组装的分子方面的新见解。
