Department of Infectious Diseases, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Microbiol Immunol. 2011 Jan;55(1):12-8. doi: 10.1111/j.1348-0421.2010.00274.x.
Infection with hepatitis C virus (HCV) is a major risk factor for chronic hepatitis, cirrhosis and hepatocellular carcinoma. Once robust cell culture systems for production of recombinant infectious HCV became available, evidence on molecular mechanisms underlying assembly and release of the virus particles began to accumulate. Recent studies have demonstrated that lipid droplets and viral nonstructural proteins play key roles in HCV morphogenesis. This review considers the current knowledge about maturation of HCV structural proteins and production of viral infectious particles.
丙型肝炎病毒（HCV）感染是慢性肝炎、肝硬化和肝细胞癌的主要危险因素。一旦生产重组传染性 HCV 的强大细胞培养系统问世，有关病毒颗粒组装和释放的分子机制的证据便开始积累。最近的研究表明，脂滴和病毒非结构蛋白在 HCV 形态发生中发挥关键作用。本文综述了 HCV 结构蛋白成熟和病毒感染性颗粒产生的最新知识。
