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使用人工真皮修复口腔黏膜缺损:与术后瘢痕挛缩相关的因素

Repair of oral mucosal defects using artificial dermis: factors related to postoperative scar contracture.

作者信息

Yura Shinya, Ooi Kazuhiro, Izumiyama Yuri

机构信息

Department of Oral and Maxillofacial Surgery, Tonami General Hospital, Tonami, Japan.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Aug;112(2):161-3. doi: 10.1016/j.tripleo.2010.08.015. Epub 2010 Dec 13.

Abstract

OBJECTIVE

To clarify wound-healing situations with artificial dermis used for the repair of oral mucosal defects, we investigated the incidence of postoperative scar contracture and studied factors related to cicatrization.

STUDY DESIGN

Forty patients who underwent repair of oral mucosal defects using artificial dermis participated in this study. The degree of scar contracture was recorded 1 month after surgery. To study the factors related to cicatrization, patient characteristics of sex, age, excision region, fixation used, size of the graft, and number of days for silicon seat removal were examined. Logistic regression analysis was used for analysis of the relationship between cicatrization and patient characteristics.

RESULTS

One month after surgery, 70% of patients had no contracture, 22.5% of patients had moderate contracture, and 7.5% of patients had severe contracture. A significant correlation was found between cicatrization and the minimum diameter of the artificial dermis (P < .001).

CONCLUSIONS

Reducing the minimum diameter of the artificial dermis may contribute to a decrease in scar contracture.

摘要

目的

为阐明用于修复口腔黏膜缺损的人工真皮的伤口愈合情况,我们调查了术后瘢痕挛缩的发生率,并研究了与瘢痕形成相关的因素。

研究设计

40例使用人工真皮修复口腔黏膜缺损的患者参与了本研究。术后1个月记录瘢痕挛缩程度。为研究与瘢痕形成相关的因素,检查了患者的性别、年龄、切除区域、使用的固定方法、移植物大小以及硅橡胶座移除天数等特征。采用逻辑回归分析来分析瘢痕形成与患者特征之间的关系。

结果

术后1个月,70%的患者无挛缩,22.5%的患者有中度挛缩,7.5%的患者有重度挛缩。发现瘢痕形成与人工真皮的最小直径之间存在显著相关性(P <.001)。

结论

减小人工真皮的最小直径可能有助于减少瘢痕挛缩。

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