Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.
Eur J Pharmacol. 2011 Feb 25;653(1-3):70-4. doi: 10.1016/j.ejphar.2010.11.024. Epub 2010 Dec 11.
Significant inter-individual variability exists in responses of human dorsal hand veins to activation of α-adrenoceptors. Simultaneous graded infusions of the α₁- and α₂-adrenoceptor agonists phenylephrine (3.66-8000 ng/min) and dexmedetomidine (0.0128-1000 ng/min) were given into dorsal veins of both hands and responses of 75 subjects were analyzed to assess whether a subject's sensitivity to phenylephrine (ED(50)) predicts his sensitivity to dexmedetomidine. Individual ED(50) estimates of dexmedetomidine and phenylephrine ranged between 0.06-412 and 14.2-7450 ng/min and exhibited only a weak positive relationship (r² =0.074, P=0.018). Finger temperature, body mass index, age and phenylephrine sensitivity together accounted for about 30% of dexmedetomidine ED(50) variation (r² =0.315, P<0.001). The large inter-individual variability observed in the responses of dorsal hand veins to both α₁- and α₂-adrenoceptor agonists is not explained by some common factors; instead, dorsal hand vein responsivity is separately determined for both receptor mechanisms.
人类手背静脉对 α-肾上腺素受体激活的反应存在显著的个体间变异性。同时将 α₁-和 α₂-肾上腺素受体激动剂苯肾上腺素（3.66-8000ng/min）和右美托咪定（0.0128-1000ng/min）以梯度输注的方式注入双手背静脉，分析了 75 名受试者的反应，以评估个体对苯肾上腺素（ED₅₀）的敏感性是否预测其对右美托咪定的敏感性。右美托咪定和苯肾上腺素的个体 ED₅₀ 估计值范围在 0.06-412 和 14.2-7450ng/min 之间，仅表现出微弱的正相关关系（r²=0.074，P=0.018）。手指温度、体重指数、年龄和苯肾上腺素敏感性共同解释了约 30%的右美托咪定 ED₅₀ 变异（r²=0.315，P<0.001）。对手背静脉对 α₁-和 α₂-肾上腺素受体激动剂反应的个体间变异性很大，无法用一些常见因素来解释；相反，两种受体机制的背侧静脉反应性是分别确定的。
