Department of Pediatrics, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital, Delhi, India.
Pediatr Neurol. 2011 Jan;44(1):35-9. doi: 10.1016/j.pediatrneurol.2010.07.005.
No data exist on the prevalence of meningitis in a first episode of seizures with fever in the Indian population. We investigated the prevalence of bacterial meningitis in children aged 6-18 months presenting with a first episode of seizures with fever, and we assessed clinical predictors of bacterial meningitis in these patients. We analyzed clinical and investigative profiles of 497 children, aged 6-18 months, admitted to pediatric casualty wards with a diagnosis of first febrile seizures. Lumbar puncture was performed in 199 (40.04%) infants. The prevalence of meningitis was 2.4% in children with first febrile seizures, 0.86% in simple febrile seizures, and 4.81% in complex febrile seizures. Duration of seizures more than 30 minutes, the presence of postictal drowsiness, and neurologic deficits were predictive of meningitis, with neurologic deficits as the most reliable. These predictors should be assessed in larger prospective studies.
在印度人群中，首次发热性惊厥发作时的脑膜炎患病率尚无数据。我们研究了 6-18 个月龄首次发热性惊厥发作患儿中细菌性脑膜炎的患病率，并评估了这些患儿中细菌性脑膜炎的临床预测因素。我们分析了 497 名 6-18 个月龄被诊断为首次热性惊厥的儿科急诊病房患儿的临床和调查资料。199 名（40.04%）婴儿进行了腰椎穿刺。首次热性惊厥患儿的脑膜炎患病率为 2.4%，单纯热性惊厥为 0.86%，复杂热性惊厥为 4.81%。发作持续时间超过 30 分钟、惊厥后嗜睡和神经功能缺损是脑膜炎的预测因素，其中神经功能缺损是最可靠的预测因素。这些预测因素应在更大的前瞻性研究中进行评估。
